Technology for reproducible polygenic scoring

Genotyping arrays or controlled genotype data are combined with quality control, harmonisation, imputation, versioned scoring, and configurable reporting.

The right input and pipeline for the score

PRS delivery depends on reliable genotype data, appropriate reference panels, reproducible model execution, and validation that matches the intended population and use.

Scalable genotype input

Genotyping arrays

Genome-wide array data for polygenic scoring, with platform-specific sample and variant QC.

Reuse controlled data

Existing genotype data

Customer or cohort data can enter through a defined format, provenance, identity, and quality review.

Coverage and comparability

Reference panels

Versioned phasing and imputation resources support the variants required by selected score models.

Reproducible calculation

Scoring pipelines

Allele alignment, model versioning, score calculation, and QC remain traceable for every result.

Population fit

Validation datasets

Calibration, discrimination, ancestry context, and local performance determine responsible interpretation.

Healthcare system integration

Starling's order and reporting environment is designed to connect securely with the systems partners already use, including EHR/EPD environments, primary-care systems, care platforms, laboratory systems, partner portals, and data warehouses. Requests, sample states, status updates, and reports can be exchanged efficiently while authorization, logging, access control, and data protection remain centrally governed.

Plug-and-play Operational integration model
APIs Orders, samples, and status flows
Secure routes Reports, messages, and file exchange

EHR, HIS, care, and partner platforms

Interfaces can be configured around existing clinical, primary-care, laboratory, and partner-platform workflows, so PRS services can be added without replacing core systems.

Orders, samples, and status updates

Secure APIs support order flows, sample activation, processing states, and implementation-specific notifications for partners and laboratories.

Reporting and secure delivery

Reports and results can be delivered through protected download routes, secure messaging, controlled file transfer, or partner-specific reporting paths.

Central authorization and audit trail

Reports and results are not shared directly from storage. Access runs through protected routes with authentication, authorization, logging, audit trails, and data minimization.

  • Secure API connections
  • Secure report downloads
  • Controlled file exchange
  • Data warehouse exports
  • Portal-facing delivery

Technology and service relationships

We combine genotyping, laboratory, and PRS analytics capabilities according to intended use, sample type, scale, and implementation setting.

Discuss a study or rollout?

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